Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 18/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3365559 | 0.91 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL3641629 | 0.89 | HCRTR1 (0.60) | HCRTR1HCRTR2HTR4 | |
| SCHEMBL3636155 | 0.88 | HCRTR1 (0.51) | HCRTR1HCRTR2 | |
| SCHEMBL3636190 | 0.86 | HCRTR1 (0.48) | HCRTR1HCRTR2HTR4 | |
| SCHEMBL3637185 | 0.86 | HCRTR1 (0.57) | HCRTR1HCRTR2HTR4 | |
| SCHEMBL3634093 | 0.86 | HCRTR1 (0.65) | HCRTR1HCRTR2 | |
| SCHEMBL3641232 | 0.86 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL3007609 | 0.84 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL3052414 | 0.84 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL3050208 | 0.84 | HCRTR1 (0.44) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | claimed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | claimed |
| EP-2155739-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008139416-A1 | 2-CYCLOPROPYL-THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-11-20 | — | — | WO | disclosed |