Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636533 | 0.89 | DRD4 (0.40) | DRD4DRD2KCNH2HTR1AKDM4E | |
| SCHEMBL3636351 | 0.87 | KCNH2 (0.40) | KCNH2SIGMAR1GRM2 | |
| SCHEMBL3633094 | 0.82 | KCNH2 (0.38) | KCNH2GRM2 | |
| SCHEMBL1224196 | 0.79 | KCNH2 (0.44) | DRD4DRD2KCNH2HTR1ATRPV1 | |
| SCHEMBL1224197 | 0.79 | KCNH2 (0.44) | DRD4DRD2KCNH2HTR1ATRPV1 | |
| SCHEMBL632837 | 0.79 | KCNH2 (0.45) | DRD4DRD2KCNH2HTR1ASIGMAR1 | |
| SCHEMBL633981 | 0.79 | KCNH2 (0.45) | DRD4DRD2KCNH2HTR1ASIGMAR1 | |
| SCHEMBL591853 | 0.78 | KCNH2 (0.47) | DRD4DRD2KCNH2HTR1AGRM2 | |
| SCHEMBL591352 | 0.78 | KCNH2 (0.47) | DRD4DRD2KCNH2HTR1AGRM2 | |
| SCHEMBL591447 | 0.78 | KCNH2 (0.47) | DRD4DRD2KCNH2HTR1AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |