Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2820374 | 1.00 | BCHE (0.54) | BCHEACHEBACE1SIGMAR1CHRM4 | |
| SCHEMBL3974690 | 1.00 | BCHE (0.54) | BCHEACHEBACE1SIGMAR1CHRM4 | |
| SCHEMBL3635928 | 0.94 | BCHE (0.53) | BCHEACHEBACE1SIGMAR1GRM5 | |
| SCHEMBL2817812 | 0.94 | BCHE (0.53) | BCHEACHEBACE1SIGMAR1GRM5 | |
| SCHEMBL2819952 | 0.92 | BCHE (0.51) | BCHEACHEBACE1SIGMAR1KDM4E | |
| SCHEMBL3632968 | 0.92 | BCHE (0.51) | BCHEACHEBACE1SIGMAR1KDM4E | |
| SCHEMBL3975652 | 0.92 | BCHE (0.51) | BCHEACHEBACE1SIGMAR1KDM4E | |
| SCHEMBL2817643 | 0.91 | BCHE (0.56) | BCHEACHEBACE1SIGMAR1CHRM4 | |
| SCHEMBL3637560 | 0.91 | BCHE (0.56) | BCHEACHEBACE1SIGMAR1CHRM4 | |
| SCHEMBL2817174 | 0.91 | BCHE (0.50) | BCHEACHEBACE1SIGMAR1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155672-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148689-A1 | PROLINAMIDE DERIVATIVES AS NK3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-12-11 | — | — | WO | disclosed |