Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3642094 | 1.00 | POLB (0.58) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10132510 | 0.95 | POLB (0.51) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6792043 | 0.95 | POLB (0.51) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18577474 | 0.81 | POLB (0.69) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18577477 | 0.81 | POLB (0.69) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10132431 | 0.81 | POLB (0.47) | POLBLTA4HHTR6 | |
| SCHEMBL10132406 | 0.81 | POLB (0.47) | POLBLTA4H | |
| SCHEMBL10132319 | 0.81 | POLB (0.47) | POLBLTA4HHTR6 | |
| Hydrochloric Acid SCHEMBL7248436 | 0.80 | POLB (0.67) | POLBLTA4HSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11474398 | 0.80 | POLB (0.67) | POLBLTA4HSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170865-A2 | NOVEL SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-04-07 | — | — | EP | claimed |
| WO-2009010660-A2 | SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-01-22 | — | — | WO | claimed |
| EP-2170865-A2 | NOVEL SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS | Sanofi-Aventis (FR) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009010660-A2 | SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2009-01-22 | — | — | WO | disclosed |