Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 5/20 | 0.49 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348968 | 0.80 | MAP2 (0.55) | MAP2PIM3MAPTPIM1ALDH1A1 | |
| SCHEMBL2349778 | 0.77 | MAP2 (0.51) | MAP2PIM3MAPTHTTPIM1 | |
| SCHEMBL2347844 | 0.75 | MAP2 (0.56) | MAP2PIM3MAPTPIM1ALDH1A1 | |
| SCHEMBL6579403 | 0.74 | KDM4E (0.53) | MAPTALDH1A1KDM4EL3MBTL1HPGD | |
| SCHEMBL2343470 | 0.74 | MAP2 (0.51) | MAP2MAPTTP53ALDH1A1HSD17B10 | |
| SCHEMBL2351116 | 0.74 | MAP2 (0.51) | MAP2PIM3MAPTPIM1ALDH1A1 | |
| SCHEMBL2346633 | 0.73 | MAP2 (0.49) | MAP2MAPTHTTTP53ALDH1A1 | |
| SCHEMBL2343430 | 0.73 | MAP2 (0.48) | MAP2PIM3MAPTPIM1ALDH1A1 | |
| SCHEMBL2349784 | 0.73 | MAP2 (0.51) | MAP2PIM3HTTPIM1ALDH1A1 | |
| SCHEMBL3606656 | 0.73 | PARP1 (0.41) | MAPTALDH1A1HSD17B10KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166856-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009158375-A1 | AZA-CYLIC INDOLE- 2 -CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2008154271-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-18 | — | — | WO | disclosed |