Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | BCHE | P06276 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.45 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.45 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3638953 | 1.00 | MAPT (0.45) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL28485825 | 0.79 | ABCG2 (0.43) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL32689424 | 0.76 | MAPT (0.53) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL3905745 | 0.72 | KMT2A (0.42) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL3905749 | 0.72 | KMT2A (0.42) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL3691676 | 0.70 | CYP3A4 (0.31) | CYP3A4 | |
| SCHEMBL27549569 | 0.69 | MAPT (0.45) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL6270921 | 0.65 | MAPT (0.46) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL29945646 | 0.65 | MAPT (0.46) | MAPTBCHELMNACYP1B1MAOB | |
| SCHEMBL8845821 | 0.65 | MAPT (0.46) | MAPTBCHELMNACYP1B1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100278784-A1 | METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS | PURETECH VENTURES (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2155146-A1 | METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS | Puretech Ventures (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008143928-A1 | METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS | PURETECH VENTURES (US) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |