Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.58 |
| ▸ | PTGDR | Q13258 | 18/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006605 | 0.93 | PTGDR2 (0.51) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2002130 | 0.81 | CYP3A4 (0.64) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2004052 | 0.73 | PTGDR (1.00) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2003584 | 0.73 | PTGDR (0.62) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2003099 | 0.73 | PTGDR2 (0.86) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2002108 | 0.71 | PTGDR (0.87) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL4501444 | 0.71 | PTGDR2 (0.86) | PTGDR2PTGDR | |
| SCHEMBL2001955 | 0.69 | CYP3A4 (1.00) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2006458 | 0.69 | PTGDR (0.60) | PTGDR2PTGDRCYP3A4 | |
| SCHEMBL2009085 | 0.68 | PTGDR (1.00) | PTGDR2PTGDRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164828-A2 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | Amgen Inc. (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008137027-A2 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |