Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643117 | 0.89 | BRAF (0.57) | BRAFCYP2C9 | |
| SCHEMBL3643371 | 0.88 | CDK8 (0.55) | BRAFKDR | |
| SCHEMBL4287982 | 0.86 | BRAF (0.57) | BRAFCYP2C9KDR | |
| SCHEMBL2857455 | 0.84 | BRAF (0.68) | BRAFCYP2C9 | |
| SCHEMBL3635535 | 0.83 | BRAF (0.46) | BRAFCYP2C9KDR | |
| SCHEMBL2853720 | 0.80 | BRAF (0.54) | BRAFCYP2C9 | |
| SCHEMBL3638529 | 0.79 | BRAF (0.57) | BRAFCYP2C9KDR | |
| SCHEMBL2190254 | 0.79 | BRAF (0.57) | BRAFCYP2C9KDR | |
| SCHEMBL4281845 | 0.76 | BRAF (0.59) | BRAFCYP2C9 | |
| SCHEMBL2851320 | 0.76 | BRAF (0.60) | BRAFCYP2C9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |