Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3642174 | 0.90 | BRAF (0.40) | MAPTMETSMN1; SMN2BRAFKDR | |
| SCHEMBL3637237 | 0.90 | MAPK14 (0.36) | MAPTALDH1A1METP2RX3BRAF | |
| SCHEMBL3513086 | 0.86 | CDK8 (0.41) | ALDH1A1SMN1; SMN2TP53KDR | |
| SCHEMBL4282370 | 0.83 | MAPT (0.43) | MAPTALDH1A1METHPGDNPSR1 | |
| SCHEMBL13636110 | 0.82 | MAPT (0.43) | MAPTALDH1A1METKDR | |
| SCHEMBL3812516 | 0.81 | KDR (0.49) | BRAFKDR | |
| SCHEMBL13636108 | 0.75 | CDK8 (0.52) | — | |
| SCHEMBL1259491 | 0.75 | TSHR (0.44) | MAPTALDH1A1METSMN1; SMN2TP53 | |
| SCHEMBL4282325 | 0.74 | NPC1 (0.39) | MAPTALDH1A1METHPGDNPSR1 | |
| SCHEMBL4280655 | 0.74 | BRAF (0.43) | MAPTMETBRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162445-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150015-A1 | HETEROBICYCLIC COMPOUNDS AS KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-11 | — | — | WO | disclosed |