Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.50 |
| ▸ | GLRB | P48167 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353484 | 0.88 | GLRA3 (0.45) | GLRA3GLRBHPGDSMKNK1MKNK2 | |
| SCHEMBL3347776 | 0.88 | GLRA3 (0.48) | GLRA3GLRBHPGDSMKNK1MKNK2 | |
| SCHEMBL6573037 | 0.83 | PRKCI (0.50) | GLRA3GLRBHPGDSPRKCI | |
| SCHEMBL5789925 | 0.82 | MKNK2 (0.51) | HPGDSMKNK1MKNK2HDAC4LTA4H | |
| SCHEMBL475724 | 0.78 | GLRA3 (0.77) | GLRA3GLRBHPGDSBRD4HDAC4 | |
| SCHEMBL3347772 | 0.78 | GLRA3 (0.44) | GLRA3GLRBHPGDSMKNK1MKNK2 | |
| SCHEMBL20256885 | 0.77 | GLRA3 (0.49) | GLRA3GLRBHPGDSBRD4HDAC4 | |
| SCHEMBL3940103 | 0.77 | GLRA3 (0.46) | GLRA3GLRBHPGDSBRD4HDAC4 | |
| SCHEMBL15131324 | 0.77 | GLRA3 (0.46) | GLRA3GLRBHPGDSDHODHBRD4 | |
| SCHEMBL2712687 | 0.76 | KDM5C (0.51) | MKNK1MKNK2MAP4K4PRKCIKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178837-A2 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009015369-A2 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |