Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 7/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813567 | 0.80 | ACACB (0.53) | ACACBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12375145 | 0.78 | PSMB5 (0.44) | PSMB5PSMB8KDM4EALDH1A1NR3C1 | |
| SCHEMBL12722551 | 0.78 | KDM4E (0.50) | PSMB5PSMB8KDM4EALDH1A1NR3C1 | |
| SCHEMBL8532416 | 0.76 | ACACB (0.82) | ACACB | |
| SCHEMBL22133095 | 0.75 | PSMB5 (0.42) | PSMB5PSMB8KDM4EALDH1A1NR3C1 | |
| SCHEMBL31544975 | 0.74 | ACACB (0.59) | ACACBNPC1RAB9A | |
| SCHEMBL11739893 | 0.74 | ACACB (0.42) | ACACB | |
| SCHEMBL3634469 | 0.73 | KDM4E (0.45) | PSMB5PSMB8KDM4EALDH1A1NR3C1 | |
| SCHEMBL11745327 | 0.73 | ACACB (0.41) | ACACB | |
| SCHEMBL3031236 | 0.73 | KDM4E (0.47) | PSMB5PSMB8KDM4EALDH1A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155751-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008136756-A1 | PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |