Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 19/20 | 0.80 |
| ▸ | SYK | P43405 | 3/20 | 0.80 |
| ▸ | JAK2 | O60674 | 1/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358095 | 0.89 | IRAK4 (0.73) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL358677 | 0.89 | IRAK4 (1.00) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL10254016 | 0.88 | IRAK4 (1.00) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL10254507 | 0.88 | IRAK4 (0.76) | IRAK4SYKJAK2JAK1TYK2 | |
| Hydrochloric Acid SCHEMBL358114 | 0.87 | IRAK4 (0.98) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL359813 | 0.86 | IRAK4 (1.00) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL359620 | 0.85 | IRAK4 (1.00) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL357362 | 0.83 | IRAK4 (1.00) | IRAK4SYKJAK2JAK1TYK2 | |
| SCHEMBL359781 | 0.81 | IRAK4 (1.00) | IRAK4JAK2JAK1TYK2JAK3 | |
| SCHEMBL19677061 | 0.80 | IRAK4 (0.70) | IRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3252054-A1 | PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2017-12-06 | — | — | EP | disclosed |
| EP-2593457-B1 | PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2017-08-23 | — | — | EP | disclosed |
| EP-2593457-A1 | PYRAZOLO [1, 5A]PYRIMIDINE AND THIENO [3, 2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |