SCHEMBL3641502

SCHEMBL3641502

c1ccc(CNc2nc(N3CCCCC3)nc3ccccc23)nc1.c1cncc(CNc2nc(N3CCCCC3)nc3ccccc23)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 7/20 0.54
HRH4 Q9H3N8 1/20 0.54
ALDH1A1 P00352 5/20 0.53
KDM4E B2RXH2 4/20 0.53
CYP1A2 P05177 4/20 0.53
CYP3A4 P08684 4/20 0.53
CYP2D6 P10635 4/20 0.53
CYP2C19 P33261 4/20 0.53
MAPT P10636 4/20 0.53
MAPK1 P28482 3/20 0.53
NPSR1 Q6W5P4 2/20 0.53
POLB P06746 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 6/20 0.52
HSD17B10 Q99714 4/20 0.52
GLA P06280 3/20 0.52
LMNA P02545 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
GAA P10253 1/20 0.52
THRB P10828 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3643245 0.92 PDE5A (0.63) PDE5AHRH4ALDH1A1KDM4ECYP1A2
SCHEMBL3638028 0.90 KDM4E (0.62) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL2592377 0.82 PDE5A (0.77) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3639211 0.82 PDE5A (0.77) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3643346 0.81 PDE5A (0.79) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3779527 0.78 KDM4E (0.58) PDE5AHRH4ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL3641716 0.77 KDM4E (0.60) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3774222 0.75 CTNNB1 (0.55) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3778305 0.75 KDM4E (0.65) PDE5AHRH4ALDH1A1KDM4EMAPT
SCHEMBL3640595 0.75 PDE5A (0.69) PDE5AHRH4ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2173346-A2 USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS Summit Corporation Plc (GB) 2010-04-14 EP disclosed
WO-2009001060-A2 USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS SUMMIT CORPORATION PLC (GB) 2008-12-31 WO disclosed