Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.41 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.41 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.41 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254700 | 0.87 | GRM5 (0.44) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL3643599 | 0.87 | GRM5 (0.59) | GRM5CYP1A2STSGPR119EED | |
| SCHEMBL3645956 | 0.84 | GRM5 (0.58) | GRM5CYP1A2STSGPR119CYP3A4 | |
| SCHEMBL3642247 | 0.83 | GRM5 (0.56) | GRM5CYP1A2GPR119CYP3A4CACNA1C | |
| SCHEMBL3640724 | 0.81 | GRM5 (0.55) | GRM5CYP1A2STSGPR119CYP3A4 | |
| SCHEMBL3645309 | 0.76 | GRM5 (0.60) | GRM5CYP1A2STSGPR119CYP3A4 | |
| SCHEMBL3638481 | 0.74 | GRM5 (0.56) | GRM5CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL4251832 | 0.72 | GRM5 (0.36) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL4256707 | 0.72 | GRM5 (0.43) | GRM5CYP1A2CYP3A4CACNA1CSCN5A | |
| SCHEMBL3639566 | 0.71 | GRM5 (1.00) | GRM5CYP1A2CYP3A4CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178858-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2010-04-28 | — | — | EP | claimed |
| WO-2009015897-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2009-02-05 | — | — | WO | claimed |