Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 14/20 | 0.49 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.49 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895062 | 0.86 | STIM1 (0.49) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2315236 | 0.82 | IL2 (0.50) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2893273 | 0.82 | STIM1 (0.50) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL7926057 | 0.80 | IL2 (0.55) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2894140 | 0.80 | IL2 (0.53) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2892211 | 0.80 | IL2 (0.49) | IL2STIM1ORAI1ORAI2 | |
| SCHEMBL15268309 | 0.79 | IL2 (0.47) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2891817 | 0.79 | STIM1 (0.53) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL15249605 | 0.79 | STIM1 (0.53) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL2892329 | 0.74 | IL2 (0.47) | IL2STIM1ORAI1ORAI2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184994-A1 | HETEROCYCLE-ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009017818-A1 | HETEROCYCLE-ARYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2009-02-05 | — | — | WO | disclosed |