Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | SCN1A | P35498 | 3/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3645502 | 1.00 | MEN1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3647583 | 1.00 | MEN1 (0.59) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL19435298 | 0.88 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL17559748 | 0.88 | MEN1 (0.63) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3640680 | 0.86 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3644829 | 0.86 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3646087 | 0.86 | MEN1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3644574 | 0.83 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3648367 | 0.83 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 | |
| SCHEMBL3649519 | 0.83 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188282-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009022311-A2 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-19 | — | — | WO | disclosed |