Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 3/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | USP1 | O94782 | 3/20 | 0.49 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639152 | 0.89 | KDM4E (0.59) | KDM4EMAPTMAPK1NPSR1PDE5A | |
| SCHEMBL3637905 | 0.89 | APP (0.63) | KDM4EAPPMAPTMAPK1NPSR1 | |
| SCHEMBL3645645 | 0.82 | APP (0.65) | KDM4EAPPMAPTMAPK1NPSR1 | |
| SCHEMBL3640774 | 0.79 | APP (0.63) | KDM4EAPPMAPTMAPK1NPSR1 | |
| SCHEMBL3639211 | 0.78 | PDE5A (0.77) | KDM4EMAPTMAPK1NPSR1PDE5A | |
| SCHEMBL2592377 | 0.78 | PDE5A (0.77) | KDM4EMAPTMAPK1NPSR1PDE5A | |
| SCHEMBL3643018 | 0.78 | KDM4E (0.58) | KDM4EMAPTMAPK1NPSR1PDE5A | |
| SCHEMBL3641147 | 0.78 | KDM4E (0.62) | KDM4EMAPTMAPK1NPSR1PDE5A | |
| SCHEMBL3644267 | 0.78 | KDM4E (0.66) | KDM4EAPPMAPTMAPK1NPSR1 | |
| SCHEMBL3644786 | 0.78 | PDE5A (0.53) | KDM4EMAPTMAPK1NPSR1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173346-A2 | USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS | Summit Corporation Plc (GB) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009001060-A2 | USE OF COMPOUNDS FOR PREPARING ANTI-TUBERCULOSIS AGENTS | SUMMIT CORPORATION PLC (GB) | 2008-12-31 | — | — | WO | disclosed |