Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646617 | 0.93 | BACE1 (0.66) | BACE1CYP3A4BACE2 | |
| SCHEMBL3510143 | 0.88 | BACE1 (0.82) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL3644965 | 0.86 | BACE1 (0.67) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL4692688 | 0.86 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL3511841 | 0.83 | BACE1 (0.81) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL4219166 | 0.83 | BACE1 (0.83) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL3506341 | 0.81 | BACE1 (0.83) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL4216477 | 0.81 | BACE1 (0.84) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL3511806 | 0.81 | BACE1 (0.83) | BACE1CYP3A4BACE2CTSD | |
| SCHEMBL4208936 | 0.81 | BACE1 (0.83) | BACE1CYP3A4BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178837-A2 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-04-28 | — | — | EP | claimed |
| WO-2009015369-A2 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2009-01-29 | — | — | WO | claimed |
| EP-2178837-A2 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY | COMENTIS, INC. (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009015369-A2 | COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |