Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219683 | 1.00 | HTT (0.71) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3651413 | 1.00 | HTT (0.71) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3696317 | 0.91 | HTT (0.72) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3692588 | 0.91 | HTT (0.72) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL13269945 | 0.90 | USP2 (0.56) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3653569 | 0.90 | USP2 (0.56) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3650375 | 0.90 | USP2 (0.56) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3650956 | 0.90 | USP2 (0.56) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3692287 | 0.89 | HTT (0.66) | HTTUSP2NPSR1SMN1; SMN2MAPT | |
| SCHEMBL3689554 | 0.89 | HTT (0.66) | HTTUSP2NPSR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188266-A2 | NOVEL PIPERAZINE AMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009021868-A2 | NOVEL PIPERAZINE AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-19 | — | — | WO | disclosed |