Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3044701 | 0.97 | NAMPT (0.54) | NAMPTPOLBKMT2AMEN1ROCK2 | |
| SCHEMBL3054771 | 0.97 | NAMPT (0.54) | NAMPTPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3044898 | 0.94 | NAMPT (0.56) | NAMPTPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3050769 | 0.88 | NAMPT (0.53) | NAMPTPOLBKMT2AMEN1ROCK2 | |
| SCHEMBL3050146 | 0.88 | NAMPT (0.56) | NAMPTPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3054341 | 0.86 | POLB (0.56) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL3049962 | 0.85 | NAMPT (0.56) | NAMPTPOLBKMT2AMEN1ROCK2 | |
| SCHEMBL3041341 | 0.85 | NAMPT (0.54) | NAMPTPOLBKMT2AMEN1 | |
| SCHEMBL3054189 | 0.84 | NAMPT (0.53) | NAMPTPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3054897 | 0.84 | NAMPT (0.52) | NAMPTPOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205566-A2 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-07-14 | — | — | EP | claimed |
| WO-2009074749-A2 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-06-18 | — | — | WO | claimed |