Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.37 |
| ▸ | RELA | Q04206 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3007016 | 0.93 | AR (0.53) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3007789 | 0.92 | AR (0.53) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3654361 | 0.84 | AR (0.52) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3021143 | 0.84 | AR (0.45) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3011535 | 0.82 | SMN1; SMN2 (0.55) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3006456 | 0.82 | SMN1; SMN2 (0.55) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3653691 | 0.82 | AR (0.51) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3017709 | 0.81 | AR (0.60) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3016053 | 0.81 | AR (0.46) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3017661 | 0.80 | SMN1; SMN2 (0.51) | ARALDH1A1SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |