Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.80 |
| ▸ | EDNRB | P24530 | 16/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | TSPO | P30536 | 1/20 | 0.71 |
| ▸ | DRD3 | P35462 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101990 | 0.89 | EDNRA (0.80) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| Aprocitentan SCHEMBL3646065 | 0.89 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| Aprocitentan SCHEMBL30439551 | 0.89 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL31266904 | 0.89 | EDNRA (0.80) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL5500351 | 0.88 | EDNRA (0.86) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL9891388 | 0.87 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL17582648 | 0.85 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL5494210 | 0.85 | EDNRA (1.00) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL1000701 | 0.84 | EDNRA (0.83) | EDNRAEDNRBSLC6A2TSPODRD3 | |
| SCHEMBL8802029 | 0.83 | EDNRB (0.84) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3105220-A1 | PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES | Actelion Pharmaceuticals Ltd (CH) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015121397-A1 | PROCESS FOR MANUFACTURING PYRIMIDINE SULFAMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2015-08-20 | — | — | WO | disclosed |
| EP-2190837-A1 | 4-PYRIMIDINESULFAMIDE DERIVATIVE | Actelion Pharmaceuticals Ltd. (CH) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024906-A1 | 4-PYRIMIDINESULFAMIDE DERIVATIVE | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-26 | — | — | WO | disclosed |