Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.83 |
| ▸ | MTOR | P42345 | 20/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55630 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CD | |
| SCHEMBL55665 | 0.90 | PIK3CA (0.84) | PIK3CAMTORPIK3CD | |
| SCHEMBL56248 | 0.89 | PIK3CA (0.82) | PIK3CAMTORPIK3CD | |
| SCHEMBL56493 | 0.89 | PIK3CA (0.76) | PIK3CAMTORPIK3CD | |
| SCHEMBL3661056 | 0.89 | PIK3CA (0.68) | PIK3CAMTOR | |
| SCHEMBL55337 | 0.88 | PIK3CA (0.80) | PIK3CAMTORPIK3CD | |
| SCHEMBL54915 | 0.88 | PIK3CA (0.94) | PIK3CAMTORPIK3CD | |
| SCHEMBL56336 | 0.87 | PIK3CA (0.79) | PIK3CAMTORPIK3CD | |
| SCHEMBL54780 | 0.87 | PIK3CA (0.79) | PIK3CAMTORPIK3CD | |
| SCHEMBL55658 | 0.87 | PIK3CA (1.00) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | disclosed |