⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1975275 | 0.82 | — | — | |
| SCHEMBL7981769 | 0.82 | — | — | |
| SCHEMBL29507088 | 0.82 | — | — | |
| SCHEMBL30391667 | 0.81 | — | — | |
| SCHEMBL10446411 | 0.81 | CFTR (0.58) | — | |
| SCHEMBL10236 | 0.81 | — | — | |
| SCHEMBL2493545 | 0.81 | CFTR (0.58) | — | |
| Hydrochloric Acid SCHEMBL20378295 | 0.80 | CFTR (0.52) | — | |
| Bromide SCHEMBL16227605 | 0.80 | CFTR (0.52) | — | |
| Hydrochloric Acid SCHEMBL27777635 | 0.80 | CFTR (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5219863-A | Treating hypertension and congestive heat failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-15 | — | — | US | claimed |
| US-5198439-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | claimed |
| US-5198434-A | ANGIOTENSIN II ANTAGONIZING FUSED PYRIDINYLOXY CONTAINING DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-03-30 | — | — | US | claimed |
| EP-0499414-A2 | Pyridine derivatives as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |
| EP-0487252-A1 | Quinoline and 1,5-Naphthyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-05-27 | — | — | EP | claimed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | claimed |
| US-9096531-B2 | Fused imidazole derivative | TOA EIYO LTD. (JP) | 2015-08-04 | — | — | US | disclosed |
| EP-2578573-A1 | FUSED IMIDAZOLE DERIVATIVE | TOA Eiyo Ltd. (JP) | 2013-04-10 | — | — | EP | disclosed |
| US-20130065896-A1 | FUSED IMIDAZOLE DERIVATIVE | TOA EIYO LTD. (JP) | 2013-03-14 | — | — | US | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| US-7223755-B2 | Hydroxymorpholinone derivative and medicinal use thereof | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-29 | — | — | US | disclosed |
| US-20050176704-A1 | Hydroxymorpholinone derivative and medicinal use thereof | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2005-08-11 | — | — | US | disclosed |
| EP-0499414-A2 | Pyridine derivatives as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| US-5130318-A | Hypotensive agents and for treatment of congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-14 | — | — | US | disclosed |
| EP-0487252-A1 | Quinoline and 1,5-Naphthyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1992-05-27 | — | — | EP | disclosed |
| EP-0453210-A2 | Pyridine derivatives | ZENECA LIMITED (GB) | 1991-10-23 | — | — | EP | disclosed |
| US-5049665-A | Cephalosporin derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-09-17 | — | — | US | disclosed |
| US-4918070-A | Antibiotics | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1990-04-17 | — | — | US | disclosed |
| EP-0280240-A2 | Cephalosporin derivatives, process for their preparation and antibacterial agents | Banyu Pharmaceutical Co., Ltd. (JP) | 1988-08-31 | — | — | EP | disclosed |