Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3006068 | 0.95 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3017122 | 0.94 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3646189 | 0.92 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3009697 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3006722 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3016435 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3007066 | 0.88 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3019103 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3020794 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 | |
| SCHEMBL3012811 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1L3MBTL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |