Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003952 | 0.94 | MAPT (0.49) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3011298 | 0.91 | MAPT (0.55) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3021331 | 0.86 | MAPK1 (0.62) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3018623 | 0.85 | AR (0.53) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3001185 | 0.85 | SMN1; SMN2 (0.51) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3016451 | 0.84 | MAPT (0.50) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3017577 | 0.83 | SMN1; SMN2 (0.53) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3009218 | 0.83 | SMN1; SMN2 (0.45) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3013827 | 0.83 | SMN1; SMN2 (0.51) | MAPTLMNAMAPK1MEN1KMT2A | |
| SCHEMBL3013793 | 0.83 | SMN1; SMN2 (0.53) | MAPTLMNAMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |