Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3020358 | 0.96 | MAPT (0.61) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3013888 | 0.94 | SMN1; SMN2 (0.64) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3010542 | 0.89 | MAPT (0.64) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3011236 | 0.88 | MAPT (0.62) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3013179 | 0.87 | SMN1; SMN2 (0.60) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL2999513 | 0.87 | MAPT (0.61) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3003209 | 0.87 | POLB (0.58) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3008752 | 0.87 | SMN1; SMN2 (0.57) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3010297 | 0.87 | MAPT (0.77) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 | |
| SCHEMBL3649567 | 0.86 | MAPT (0.61) | MAPTUSP2RECQLHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |