Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3010501 | 0.97 | POLB (0.60) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3001171 | 0.93 | SMN1; SMN2 (0.60) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3014175 | 0.91 | MAPT (0.59) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3644339 | 0.88 | MAPT (0.57) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3015112 | 0.88 | SMN1; SMN2 (0.66) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3006945 | 0.88 | SMN1; SMN2 (0.66) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3016305 | 0.88 | MAPT (0.71) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3003575 | 0.88 | SMN1; SMN2 (0.52) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL3016363 | 0.88 | SMN1; SMN2 (0.58) | POLBMAPTUSP2RECQLHSD17B10 | |
| SCHEMBL2999988 | 0.87 | SMN1; SMN2 (0.53) | POLBMAPTUSP2RECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |