Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSHR | P23945 | 16/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194582 | 0.85 | FSHR (0.61) | FSHRTSHRNPC1MAPTRAB9A | |
| SCHEMBL2196163 | 0.85 | TSHR (0.61) | FSHRTSHRNPC1TP53RAB9A | |
| SCHEMBL2192026 | 0.85 | TSHR (0.68) | FSHRTSHR | |
| SCHEMBL2194212 | 0.85 | TSHR (0.61) | FSHRTSHRNPC1TP53RAB9A | |
| SCHEMBL2193028 | 0.83 | FSHR (0.53) | FSHRTSHRNPC1TP53MAPT | |
| SCHEMBL2192031 | 0.83 | TSHR (0.59) | FSHRTSHRNPC1TP53RAB9A | |
| SCHEMBL2193480 | 0.82 | TSHR (0.65) | FSHRTSHRNPC1MAPTRAB9A | |
| SCHEMBL2194165 | 0.82 | TSHR (0.65) | FSHRTSHR | |
| SCHEMBL2193665 | 0.82 | FSHR (0.63) | FSHRTSHRMAPT | |
| SCHEMBL2192676 | 0.81 | TSHR (0.64) | FSHRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197445-B1 | TSH RECEPTOR ANTAGONIZING TETRAHYDROQUINOLINE COMPOUNDS | MERCK SHARP & DOHME (NL) | 2017-04-19 | — | — | EP | claimed |
| US-9174940-B2 | TSH receptor antagonizing tetrahydroquinoline compounds | MERCK SHARP & DOHME B.V. (NL) | 2015-11-03 | — | — | US | claimed |
| EP-2197445-A2 | TSH RECEPTOR ANTAGONIZING TETRAHYDROQUINOLINE COMPOUNDS | N.V. Organon (NL) | 2010-06-23 | — | — | EP | claimed |
| WO-2009027482-A2 | TSH RECEPTOR ANTAGONIZING TETRAHYDROQUINOLINE COMPOUNDS | N.V. ORGANON (NL) | 2009-03-05 | — | — | WO | claimed |
| EP-2197445-B1 | TSH RECEPTOR ANTAGONIZING TETRAHYDROQUINOLINE COMPOUNDS | MERCK SHARP & DOHME (NL) | 2017-04-19 | — | — | EP | disclosed |
| US-9174940-B2 | TSH receptor antagonizing tetrahydroquinoline compounds | MERCK SHARP & DOHME B.V. (NL) | 2015-11-03 | — | — | US | disclosed |