Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.78 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.78 |
| ▸ | HCK | P08631 | 9/20 | 0.78 |
| ▸ | TNF | P01375 | 5/20 | 0.78 |
| ▸ | CIT | O14578 | 1/20 | 0.74 |
| ▸ | MUSK | O15146 | 1/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.74 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
| ▸ | STK10 | O94804 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | RAF1 | P04049 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.74 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.74 |
| ▸ | PRKCB | P05771 | 1/20 | 0.74 |
| ▸ | LCK | P06239 | 1/20 | 0.74 |
| ▸ | FYN | P06241 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298579 | 0.92 | MAPK14 (0.79) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL295686 | 0.88 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL29593358 | 0.88 | MAPK14 (1.00) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL296321 | 0.88 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29594554 | 0.88 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6680086 | 0.87 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL295612 | 0.87 | MAPK14 (0.92) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL29594379 | 0.87 | MAPK14 (0.92) | MAPK14MAPK12HCKTNFSRC | |
| SCHEMBL12444980 | 0.87 | MAPK14 (0.85) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29594407 | 0.86 | MAPK14 (0.72) | MAPK14MAPK12HCKTNFCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975285-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2015-03-10 | — | — | US | disclosed |
| US-8975285-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2015-03-10 | — | — | US | disclosed |
| US-20140114064-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2014-04-24 | — | — | US | disclosed |
| US-8618140-B2 | P38 MAP kinase inhibitors | RESPIVERT LTD (GB) | 2013-12-31 | — | — | US | disclosed |
| US-20130012512-A1 | P38 MAP kinase inhibitors | ITO KAZUHIRO (GB) | 2013-01-10 | — | — | US | disclosed |
| US-20130012512-A1 | P38 MAP kinase inhibitors | ITO KAZUHIRO (GB) | 2013-01-10 | — | — | US | disclosed |
| US-8293748-B2 | p38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-23 | — | — | US | disclosed |
| US-8293748-B2 | p38 MAP kinase inhibitors | RESPIVERT LTD. (GB) | 2012-10-23 | — | — | US | disclosed |
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2011-09-01 | — | — | US | disclosed |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LTD. (GB) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012512-A1 | P38 MAP kinase inhibitors | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
| US-20110212962-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
| US-20140114064-A1 | P38 MAP KINASE INHIBITORS | MAPK1, MAPK3, MAPK6 | MAPK14 33/4885MAPK12 31/4885HCK 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.