Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | AKT1 | P31749 | 6/20 | 0.36 |
| ▸ | AKT2 | P31751 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652666 | 0.90 | AKT1 (0.38) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3655001 | 0.86 | JAK1 (0.38) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3647805 | 0.78 | JAK3 (0.38) | JAK1JAK2AKT2JAK3TYK2 | |
| SCHEMBL4438467 | 0.75 | AAK1 (0.40) | JAK1JAK2AKT1JAK3BRAF | |
| SCHEMBL4440002 | 0.75 | JAK1 (0.39) | JAK1JAK2AKT1JAK3BRAF | |
| SCHEMBL3650729 | 0.74 | JAK3 (0.37) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3657737 | 0.74 | JAK3 (0.40) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3650425 | 0.74 | JAK3 (0.38) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3653928 | 0.73 | JAK3 (0.39) | JAK1JAK2AKT1AKT2JAK3 | |
| SCHEMBL3653319 | 0.73 | JAK3 (0.40) | JAK1JAK2AKT1AKT2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |