Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652423 | 0.98 | EEF2K (0.39) | EEF2KIKBKBMELKBRAFADORA1 | |
| SCHEMBL3655138 | 0.94 | EEF2K (0.40) | EEF2KIKBKBBRAFADORA1HSP90AB1 | |
| SCHEMBL3652451 | 0.93 | EEF2K (0.39) | EEF2KIKBKBBRAFADORA1HSP90AB1 | |
| SCHEMBL3651201 | 0.93 | EEF2K (0.40) | EEF2KIKBKBBRAFADORA1HSP90AB1 | |
| SCHEMBL3652813 | 0.92 | EEF2K (0.41) | EEF2KIKBKBMELKBRAFADORA1 | |
| SCHEMBL3651076 | 0.92 | EEF2K (0.38) | EEF2KIKBKBBRAFHSP90AB1MEN1 | |
| SCHEMBL14312220 | 0.90 | EEF2K (0.37) | EEF2KIKBKBBRAFHSP90AB1MEN1 | |
| SCHEMBL3648990 | 0.89 | EEF2K (0.38) | EEF2KIKBKBBRAFADORA1HSP90AB1 | |
| SCHEMBL3652480 | 0.88 | EEF2K (0.41) | EEF2KIKBKBALDH1A1HPGD | |
| SCHEMBL3088406 | 0.88 | EEF2K (0.53) | EEF2KIKBKBMELKBRAFHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197886-B1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | claimed |
| EP-2197886-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-06-23 | — | — | EP | claimed |
| WO-2009049743-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | WO | claimed |
| EP-2197886-B1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |