Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.69 |
| ▸ | JAK2 | O60674 | 9/20 | 0.65 |
| ▸ | JAK3 | P52333 | 4/20 | 0.65 |
| ▸ | TYK2 | P29597 | 2/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | SYK | P43405 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.57 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031287 | 0.84 | JAK1 (0.79) | JAK1JAK2JAK3TYK2IKBKB | |
| Cyclopropane SCHEMBL16986941 | 0.81 | JAK1 (0.73) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13031288 | 0.81 | JAK1 (1.00) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL3584534 | 0.81 | JAK1 (0.73) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13031296 | 0.80 | JAK1 (0.72) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13031290 | 0.80 | JAK1 (0.81) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13031173 | 0.79 | JAK1 (1.00) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13033022 | 0.79 | JAK2 (0.79) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13072782 | 0.79 | JAK2 (0.74) | JAK1JAK2JAK3TYK2IKBKB | |
| SCHEMBL13031291 | 0.78 | JAK1 (0.78) | JAK1JAK2JAK3TYK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |