Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.60 |
| ▸ | AKT2 | P31751 | 7/20 | 0.60 |
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | LATS1 | O95835 | 2/20 | 0.52 |
| ▸ | PRKCB | P05771 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | PRKACB | P22694 | 2/20 | 0.52 |
| ▸ | GRK2 | P25098 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654806 | 0.92 | AKT1 (0.61) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL392415 | 0.89 | AKT1 (0.75) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL3655529 | 0.89 | AKT1 (0.57) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL392234 | 0.88 | AKT1 (0.74) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL387935 | 0.88 | AKT1 (0.73) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL3651769 | 0.87 | AKT1 (0.55) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL391016 | 0.86 | AKT1 (0.74) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL390778 | 0.86 | AKT1 (0.73) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL390565 | 0.86 | AKT1 (0.73) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL392172 | 0.85 | AKT1 (0.73) | AKT1ROCK2AKT2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |