Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656598 | 0.91 | EEF2K (0.41) | EEF2KKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL14312146 | 0.89 | EEF2K (0.40) | EEF2KKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14312330 | 0.88 | EEF2K (0.41) | EEF2KADORA2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3092291 | 0.88 | EEF2K (0.56) | EEF2KADORA2AKDM4EALDH1A1MAPT | |
| SCHEMBL3655914 | 0.88 | EEF2K (0.42) | EEF2KADORA2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3657555 | 0.85 | EEF2K (0.46) | EEF2KADORA2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3655139 | 0.85 | EEF2K (0.36) | EEF2KKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL3656989 | 0.83 | KDM4E (0.41) | EEF2KKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL3647504 | 0.81 | EEF2K (0.40) | EEF2KADORA2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3087819 | 0.79 | EEF2K (0.55) | EEF2KKDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197886-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | Merck Patent GmbH (DE) | 2010-06-23 | — | — | EP | claimed |
| WO-2009049743-A1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | WO | claimed |
| EP-2197886-B1 | 5-CYANO-THIENOPYRIDINES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |