Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.70 |
| ▸ | MTOR | P42345 | 20/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.70 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.70 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL54445 | 0.89 | PIK3CA (0.72) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL3659164 | 0.85 | PIK3CA (0.69) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL3656780 | 0.85 | PIK3CA (0.87) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL3657075 | 0.84 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL55058 | 0.84 | PIK3CA (0.75) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL55078 | 0.83 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| Methyl Alcohol SCHEMBL3658444 | 0.83 | PIK3CA (0.84) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL54355 | 0.83 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL55349 | 0.83 | PIK3CA (0.73) | PIK3CAMTORPIK3CDPIK3R1SMG1 | |
| SCHEMBL54821 | 0.83 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1SMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | claimed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | claimed |