Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | MTOR | P42345 | 20/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | ATR | Q13535 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55805 | 0.85 | PIK3CA (0.57) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL55473 | 0.85 | PIK3CA (0.80) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL55455 | 0.84 | PIK3CA (0.79) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL55929 | 0.84 | MTOR (0.55) | PIK3CAMTOR | |
| SCHEMBL55164 | 0.84 | PIK3CA (0.65) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL56007 | 0.82 | PIK3CA (0.70) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL54445 | 0.82 | PIK3CA (0.72) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL54217 | 0.81 | PIK3CA (0.81) | PIK3CAMTORPIK3CGATRAURKB | |
| SCHEMBL55555 | 0.80 | MTOR (0.68) | PIK3CAMTOR | |
| SCHEMBL56330 | 0.80 | PIK3CA (0.62) | PIK3CAMTORPIK3CGATRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | disclosed |