Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 20/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3654624 | 0.93 | HRH1 (0.64) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3652229 | 0.86 | HRH1 (0.56) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3655193 | 0.86 | HRH1 (0.56) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3045121 | 0.83 | HRH1 (0.68) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3056335 | 0.83 | HRH1 (0.68) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3050291 | 0.83 | HRH1 (0.68) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3046867 | 0.83 | HRH1 (0.63) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL13178270 | 0.83 | HRH1 (0.71) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3054855 | 0.83 | HRH1 (0.67) | HRH1KCNH2CYP3A4CYP2D6CHRM1 | |
| SCHEMBL3054378 | 0.81 | HRH1 (0.69) | HRH1KCNH2CYP3A4CYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205585-A1 | QUINOLINE DERIVATIVES USED TO TREAT INFLAMMATORY AND ALLERGIC DISEASES | Glaxo Group Limited (GB) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009050204-A1 | QUINOLINE DERIVATIVES USED TO TREAT INFLAMMATORY AND ALLERGIC DISEASES | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |