Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 1.00 |
| ▸ | GSK3B | P49841 | 8/20 | 1.00 |
| ▸ | NFATC1 | O95644 | 1/20 | 1.00 |
| ▸ | CDK2 | P24941 | 4/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.70 |
| ▸ | PIM1 | P11309 | 2/20 | 0.70 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.69 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.69 |
| ▸ | CLK1 | P49759 | 4/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.63 |
| ▸ | PRKACA | P17612 | 3/20 | 0.63 |
| ▸ | PRKACG | P22612 | 3/20 | 0.63 |
| ▸ | PRKACB | P22694 | 3/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12701223 | 0.88 | GSK3B (0.79) | DYRK1AGSK3BNFATC1CDK2DYRK1B | |
| SCHEMBL27142194 | 0.82 | DYRK1A (0.70) | DYRK1AGSK3BNFATC1CDK2DYRK1B | |
| SCHEMBL29488162 | 0.82 | GSK3B (1.00) | DYRK1AGSK3BNFATC1CDK2PIM1 | |
| SCHEMBL573402 | 0.82 | GSK3B (1.00) | DYRK1AGSK3BNFATC1CDK2PIM1 | |
| SCHEMBL27849262 | 0.80 | DYRK1A (0.66) | DYRK1AGSK3BNFATC1CDK2DYRK1B | |
| SCHEMBL13051138 | 0.79 | DYRK1A (0.65) | DYRK1AGSK3BNFATC1CDK2DYRK1B | |
| SCHEMBL16205676 | 0.79 | GSK3B (0.71) | DYRK1AGSK3BNFATC1CDK2PIM1 | |
| SCHEMBL23175317 | 0.77 | GSK3B (0.71) | DYRK1AGSK3BNFATC1CDK2PIM1 | |
| Meridianin D SCHEMBL31094009 | 0.77 | GSK3B (1.00) | DYRK1AGSK3BNFATC1CDK2PIM1 | |
| SCHEMBL29488165 | 0.77 | MAP3K14 (0.80) | DYRK1AGSK3BNFATC1CDK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | claimed |
| EP-3039015-B1 | SUBSTITUTED PYRIMIDINE BMI-1 INHIBITORS | PTC THERAPEUTICS INC (US) | 2019-10-30 | — | — | EP | disclosed |
| CN-101918404-A | 4-(pyrrolo[2,3-c]pyridine-3-yl)-pyrimidine-2-amine derivatives | MERCK PATENT GMBH | 2010-12-15 | — | — | CN | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-11-18 | — | — | US | disclosed |
| EP-2231664-A1 | 4-(PYRROLOÝ2,3-C¨PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009092431-A1 | 4-(PYRROLO[2,3-C]PYRIDINE-3-YL)-PYRIMIDINE-2-AMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292262-A1 | 4 (PYRROLO[2,3-C]PYRIDINE-3-YL)PYRIMIDIN-2-AMINE DERIVATIVES | MKI67, CDK4, CCNT1 | DYRK1A 2428/4885GSK3B 1642/4885NFATC1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.