Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3081532 | 0.97 | PARP1 (0.53) | PARP1PARP2 | |
| SCHEMBL15988465 | 0.92 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL15988423 | 0.90 | PARP1 (0.58) | PARP1PARP2 | |
| SCHEMBL15988435 | 0.90 | PARP1 (0.58) | PARP1PARP2 | |
| Trifluoroacetic Acid SCHEMBL3063430 | 0.89 | PARP1 (0.54) | PARP1PARP2 | |
| Trifluoroacetic Acid SCHEMBL3082902 | 0.89 | PARP1 (0.54) | PARP1PARP2 | |
| Trifluoroacetic Acid SCHEMBL3083043 | 0.89 | PARP1 (0.54) | PARP1PARP2 | |
| SCHEMBL15988392 | 0.86 | PARP1 (0.67) | PARP1 | |
| SCHEMBL12342209 | 0.86 | PARP1 (0.67) | PARP1 | |
| SCHEMBL30418013 | 0.85 | PARP1 (0.68) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-B1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | MSD ITALIA SRL (IT) | 2014-09-03 | — | — | EP | claimed |
| EP-2220073-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063244-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-05-22 | — | — | WO | disclosed |