Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.67 |
| ▸ | MTOR | P42345 | 20/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.55 |
| ▸ | ATR | Q13535 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55731 | 0.92 | PIK3CA (0.80) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL53026 | 0.85 | PIK3CA (0.83) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL55405 | 0.83 | PIK3CA (0.77) | PIK3CAMTOR | |
| SCHEMBL3654553 | 0.83 | PIK3CA (0.65) | PIK3CAMTORPIK3CG | |
| SCHEMBL55818 | 0.82 | PIK3CA (0.87) | PIK3CAMTORPIK3CGATR | |
| Hydrochloric Acid SCHEMBL56134 | 0.82 | PIK3CA (0.76) | PIK3CAMTOR | |
| SCHEMBL4563300 | 0.81 | PIK3CA (0.78) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL56098 | 0.80 | PIK3CA (0.86) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL55501 | 0.80 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3983804 | 0.80 | PIK3CA (0.75) | PIK3CAMTORPIK3CGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | disclosed |