Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366730 | 0.85 | NR4A2 (0.43) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL365900 | 0.83 | MAPT (0.43) | IDO1GAAKMT2AMEN1LMNA | |
| SCHEMBL366305 | 0.82 | NR4A2 (0.41) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL365054 | 0.79 | NR4A2 (0.46) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL364533 | 0.78 | NR4A2 (0.45) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL367527 | 0.78 | NR4A2 (0.41) | NR4A2GAAKMT2AMEN1LMNA | |
| SCHEMBL364933 | 0.77 | NR4A2 (0.42) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL366483 | 0.73 | NR4A2 (0.40) | NR4A2IDO1GAAKMT2AMEN1 | |
| SCHEMBL364927 | 0.73 | SRC (0.51) | NR4A2GAAKMT2AMEN1LMNA | |
| SCHEMBL364931 | 0.73 | NR4A2 (0.50) | NR4A2IDO1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |