Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.76 |
| ▸ | PRKCI | P41743 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL55958 | 0.86 | MTOR (1.00) | MTORPIK3CAPRKCI | |
| SCHEMBL55812 | 0.86 | MTOR (1.00) | MTORPIK3CAPRKCI | |
| SCHEMBL55752 | 0.82 | MTOR (1.00) | MTORPIK3CAPRKCI | |
| SCHEMBL55781 | 0.80 | MTOR (0.63) | MTORPIK3CAPRKCI | |
| SCHEMBL55500 | 0.80 | MTOR (1.00) | MTORPIK3CAPRKCI | |
| SCHEMBL55723 | 0.80 | PIK3CA (1.00) | MTORPIK3CA | |
| Hydrochloric Acid SCHEMBL56427 | 0.79 | MTOR (0.62) | MTORPIK3CAPRKCI | |
| SCHEMBL53786 | 0.79 | MTOR (1.00) | MTORPIK3CA | |
| SCHEMBL56648 | 0.78 | MTOR (0.70) | MTORPIK3CAPRKCI | |
| SCHEMBL55840 | 0.78 | MTOR (1.00) | MTORPIK3CAPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | claimed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | claimed |
| EP-2212333-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth LLC (US) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052145-A1 | THIENOPYRIMIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2009-04-23 | — | — | WO | disclosed |