Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141759 | 1.00 | DDB1 (0.48) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL24093870 | 0.96 | DDB1 (0.49) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL10670488 | 0.96 | DDB1 (0.49) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL6507174 | 0.82 | DDB1 (0.47) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7370052 | 0.82 | DDB1 (0.47) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11227277 | 0.81 | DDB1 (0.43) | DDB1CRBNALDH1A1 | |
| SCHEMBL11227280 | 0.81 | DDB1 (0.43) | DDB1CRBNALDH1A1 | |
| SCHEMBL17157158 | 0.81 | DDB1 (0.48) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7545247 | 0.80 | DDB1 (0.43) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL11285714 | 0.78 | DDB1 (0.52) | DDB1CRBNALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220073-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063244-A1 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-05-22 | — | — | WO | disclosed |