Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.46 |
| ▸ | PDE2A | O00408 | 5/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970788 | 0.93 | RPS6KA5 (0.47) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL973647 | 0.88 | PDE10A (0.56) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL970200 | 0.86 | PDE10A (0.49) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL971457 | 0.86 | TLR7 (0.52) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL969451 | 0.81 | PDE10A (0.60) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL971822 | 0.81 | PDE10A (0.63) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL970412 | 0.76 | PDE10A (0.52) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL3660549 | 0.76 | PDE10A (0.64) | PDE10APDE2APDE5APDE4APDE4D | |
| SCHEMBL3667892 | 0.75 | PDE2A (0.47) | PDE10APDE2APDE4APDE4DPDE7A | |
| SCHEMBL970509 | 0.75 | PDE10A (0.58) | PDE10APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225248-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | Wyeth LLC (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009070584-A1 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-A]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2009-06-04 | — | — | WO | disclosed |