Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | TPMT | P51580 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Veratric Acid Methyl Ester SCHEMBL2371276 | 0.98 | MAPT (0.70) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| Veratric Acid Methyl Ester SCHEMBL2050732 | 0.91 | MAPT (0.86) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| Veratric Acid Methyl Ester SCHEMBL29573244 | 0.91 | MAPT (0.86) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| SCHEMBL12604683 | 0.85 | NOTUM (0.56) | MAPTKMT2ATSHRCYP2C9CA12 | |
| Veratric Acid Methyl Ester SCHEMBL22717084 | 0.84 | MAPT (0.75) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| SCHEMBL31156002 | 0.83 | MAPT (0.51) | MAPTKMT2ACA12CA1CA2 | |
| SCHEMBL31265461 | 0.83 | MAPT (0.54) | MAPTKMT2ATSHRCA12CA1 | |
| SCHEMBL23480903 | 0.81 | MAPT (0.70) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| SCHEMBL4529606 | 0.81 | CYP1A2 (0.79) | MAPTKMT2ATSHRCYP2C9CYP1A2 | |
| SCHEMBL12554591 | 0.81 | MAPT (0.70) | MAPTKMT2ATSHRCYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133137-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2242493-B1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20110059046-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2011-03-10 | — | — | US | disclosed |
| US-7855204-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855204-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS INC. (US) | 2010-12-21 | — | — | US | disclosed |
| EP-2242493-A1 | DERIVATIVES OF GEFITINIB | Concert Pharmaceuticals Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009094216-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-30 | — | — | WO | disclosed |
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-23 | — | — | US | disclosed |
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | ABL1, EGFR, ERBB2 | MAPT 4547/4885KMT2A 2604/4885TSHR 1339/4885 |
| US-20110059046-A1 | DERIVATIVES OF GEFITINIB | ABL1, EGFR, ERBB2 | MAPT 4547/4885KMT2A 2604/4885TSHR 1339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.