Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.83 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372600 | 0.91 | KDM4E (1.00) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL31408659 | 0.91 | KDM4E (1.00) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL12604682 | 0.87 | KDM4E (0.63) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL2900351 | 0.82 | KDM4E (0.82) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL1781100 | 0.82 | KDM4E (0.56) | KDM4EGAAALDH1A1HSD17B10HPGD | |
| SCHEMBL8102912 | 0.81 | KDM4E (0.53) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL2189622 | 0.81 | KDM4E (0.79) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL2857865 | 0.81 | KDM4E (0.78) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL1012737 | 0.81 | KDM4E (0.78) | KDM4EGAAPOLBALDH1A1HSD17B10 | |
| SCHEMBL6383531 | 0.81 | KDM4E (0.78) | KDM4EGAAPOLBALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133137-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2242493-B1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20110059046-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2011-03-10 | — | — | US | disclosed |
| US-7855204-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS INC. (US) | 2010-12-21 | — | — | US | disclosed |
| US-7855204-B2 | Derivatives of gefitinib | CONCERT PHARMACEUTICALS INC. (US) | 2010-12-21 | — | — | US | disclosed |
| EP-2242493-A1 | DERIVATIVES OF GEFITINIB | Concert Pharmaceuticals Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009094216-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-30 | — | — | WO | disclosed |
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-23 | — | — | US | disclosed |
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | CONCERT PHARMACEUTICALS INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090185999-A1 | DERIVATIVES OF GEFITINIB | ABL1, EGFR, ERBB2 | KDM4E 3127/4885GAA 916/4885POLB 3426/4885 |
| US-20110059046-A1 | DERIVATIVES OF GEFITINIB | ABL1, EGFR, ERBB2 | KDM4E 3127/4885GAA 916/4885POLB 3426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.