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SCHEMBL3662376

SCHEMBL3662376

Cc1cc(Br)cc(C(C)C(=O)Nc2ccc(-c3ccnc(C)c3)cc2)c1.Cc1cc(C(C)C(=O)Nc2ccc(-c3ccnc(C)c3)cc2)cc(N2CCN(c3ccccn3)CC2)c1

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 19/20 0.63
▸ PSEN2 P49810 19/20 0.63
▸ APH1B Q8WW43 19/20 0.63
▸ NCSTN Q92542 19/20 0.63
▸ APH1A Q96BI3 19/20 0.63
▸ PSENEN Q9NZ42 19/20 0.63
▸ CYP2D6 P10635 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2185249 0.95 PSEN1 (0.69) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL3662378 0.86 PSEN1 (0.45) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2183146 0.84 PSEN1 (0.85) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2184594 0.81 PSEN1 (0.70) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2183624 0.80 PSEN1 (0.67) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2185126 0.78 PSEN1 (1.00) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2185319 0.75 PSEN1 (0.91) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2184271 0.75 PSEN1 (0.71) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2185632 0.75 PSEN1 (0.71) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL2183196 0.74 PSEN1 (0.80) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2231602-A1 GAMMA SECRETASE MODULATORS Amgen, Inc (US) 2010-09-29 — — EP disclosed
WO-2009075874-A1 GAMMA SECRETASE MODULATORS AMGEN INC. (US) 2009-06-18 — — WO disclosed