Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 6/20 | 0.79 |
| ▸ | PDE1A | P54750 | 4/20 | 0.79 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.79 |
| ▸ | PDE2A | O00408 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE8A | O60658 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1654131 | 0.91 | PDE1B (0.95) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL11962052 | 0.91 | PDE1B (0.95) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL8045666 | 0.90 | PDE1B (0.80) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL1654115 | 0.88 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL11962054 | 0.88 | PDE1B (1.00) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL11903636 | 0.88 | PDE1B (0.79) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL1652846 | 0.87 | PDE1B (0.73) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL16130289 | 0.87 | PDE1B (0.79) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL1653711 | 0.85 | PDE1B (0.76) | PDE1BPDE1APDE1CPDE2APDE4D | |
| SCHEMBL3094574 | 0.85 | PDE1B (0.76) | PDE1BPDE1APDE1CPDE2APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240028-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009073210-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC (US) | 2009-06-11 | — | — | WO | disclosed |