Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828421 | 0.99 | HRH3 (0.72) | HRH3KCNH2ADRA1A | |
| SCHEMBL4468612 | 0.84 | HRH3 (0.98) | HRH3KCNH2ADRA1A | |
| SCHEMBL2001771 | 0.83 | HRH3 (0.64) | HRH3KCNH2ADRA1A | |
| SCHEMBL4480836 | 0.82 | HRH3 (0.98) | HRH3KCNH2ADRA1A | |
| Hydrochloric Acid SCHEMBL4467810 | 0.81 | HRH3 (0.98) | HRH3KCNH2ADRA1A | |
| SCHEMBL4461471 | 0.81 | HRH3 (0.80) | HRH3KCNH2ADRA1A | |
| SCHEMBL4473018 | 0.80 | HRH3 (1.00) | HRH3KCNH2ADRA1A | |
| SCHEMBL15555742 | 0.80 | HRH3 (0.76) | HRH3KCNH2ADRA1A | |
| SCHEMBL4485049 | 0.80 | HRH3 (1.00) | HRH3KCNH2ADRA1A | |
| SCHEMBL4474003 | 0.80 | HRH3 (0.76) | HRH3KCNH2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398483-A1 | OXYNTOMODULIN ANALOGS | Merck Sharp & Dohme Corp. (US) | 2011-12-28 | — | — | EP | disclosed |
| WO-2010096142-A1 | OXYNTOMODULIN ANALOGS | MERCK SHARP & DOHME, CORP. (US) | 2010-08-26 | — | — | WO | disclosed |
| EP-2139333-A1 | SUBSTITUTED PYRIDO[3,2-E][1,2,4]TRIAZOLO[4,3-C]PYRIMIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118414-A1 | SUBSTITUTED PYRIDO[3,2-E][1,2,4]TRIAZOLO[4,3-C]PYRIMIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-10-02 | — | — | WO | disclosed |